Next Generation Sequencing and immune gene evolution: a comparative approach

0425724 - ÚBO 2014 CZ eng A - Abstrakt
Winternitz, Jamie Caroline - Bryja, Josef
Next Generation Sequencing and immune gene evolution: a comparative approach.
Zoologické dny Ostrava 2014: sborník abstraktů z konference 6.-7. února 2014. Brno: Ústav biologie obratlovců AV ČR, 2014 - (Bryja, J.; Drozd, P.). s. 221. ISBN 978-80-87189-16-0.
[Zoologické dny. 06.02.2014-07.02.2014, Ostrava]
Grant CEP: GA MŠMT EE2.3.35.0026
Institucionální podpora: RVO:68081766
Klíčová slova: major histocompatibility complex
Kód oboru RIV: EG - Zoologie

The major histocompatibility complex (MHC) is arguably the the most diverse and intensively studied gene of the vertebrate immune system, yet the ecological and evolutionary factors shaping its extraordinary variability across species are poorly understood. This complex serves as an outstanding model for deepening understanding of the natural process promoting adaptive variation in wild populations. Focusing on one of the most diverse groups of vertebrates, we intend to characterize MHC Class II DRB polymorphism across the radiation of Asian and African rodents and, using a comparative approach, identify the main drivers of interspecific MHC variation. In addition, there is currently debate about the processes promoting alleles shared between species. We will consider evidence for the role of selection maintaining alleles across speciation events vs. allelic similarity due to gene convergence.
Trvalý link: http://hdl.handle.net/11104/0231600