Počet záznamů: 1
Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ
- 1.0425635 - MBÚ 2014 RIV DE eng J - Článek v odborném periodiku
Najmanová, Lucie - Kutejová, Eva - Kadlec, J. - Polan, M. - Olšovská, Jana - Benada, Oldřich - Novotná, Jitka - Kameník, Zdeněk - Halada, Petr - Bauer, J. - Janata, Jiří
Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ.
Chembiochem. Roč. 14, č. 17 (2013), s. 2259-2262. ISSN 1439-4227. E-ISSN 1439-7633
Grant CEP: GA MŠMT(CZ) EE2.3.20.0055; GA MŠMT(CZ) EE2.3.30.0003
Institucionální podpora: RVO:61388971
Klíčová slova: antibiotics * lincomycin * natural products
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.060, rok: 2013
Two putative methyltrasferases LmbJ and CcbJ from the biosynthesis of lincosamide antibiotics lincomycin and celesticetin respectively, were characterized biochemicalla and confirmed do possess a homooligomeric, probably hexameric quaternary structure. LmbJ was confirmed to convert N-demethyl lincomycin. CcbJ is able to catalyze the same reaction with comparable efficiency, indicating tha its substrate specificity is somewhat relaxed.
Trvalý link: http://hdl.handle.net/11104/0231440
Počet záznamů: 1