Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells

0425607 - FZÚ 2014 CZ eng A - Abstrakt
Novotná, Božena - Turnovcová, Karolína - Veverka, Miroslav - Rössner ml., Pavel - Bagryantseva, Yana - Herynek, V. - Syková, Eva - Jendelová, Pavla
Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells.
2nd QNano Integrating Conference. 2013. s. 160-160.
[QNano Integrating Conference /2./. 27.02.2013-01.03.2013, Praha]
Grant CEP: GA ČR(CZ) GAP304/12/1370
Institucionální podpora: RVO:68378271 ; RVO:68378041
Klíčová slova: safety * cobalt zinc ferrite * contrast agent * cell labeling
Kód oboru RIV: FP - Ostatní lékařské obory

To monitor the fate of transplanted cells within the organism, several non-invasive techniques have been introduced, including magnetic resonance imaging (MRI) of cells labeled with a contrast agent prior to grafting. Our previous study demonstrated a severe oxidative injury to lipids, proteins and DNA of human bone marrow mesenchymal stem cells as a result of their labeling with superparamagnetic iron oxide nanoparticles (SPIONs). CZF nanoparticles represent another type of contrast agent based not only on iron, but also on cobalt and zinc (Co0.5Zn0.5Fe2O4+γ), with a ferrite core encapsulated by amorphous silica. The present study was performed with the aim of determining the safe concentration of CZF nanoparticles with respect to oxidative damage to biological macromolecules.
Trvalý link: http://hdl.handle.net/11104/0231431