Numerical aspects of optimal control of penicillin production

0424718 - ÚTIA 2015 RIV DE eng J - Článek v odborném periodiku
Pčolka, M. - Čelikovský, Sergej
Numerical aspects of optimal control of penicillin production.
Bioprocess and Biosystems Engineering. Roč. 37, č. 1 (2014), s. 71-81. ISSN 1615-7591. E-ISSN 1615-7605
Grant CEP: GA ČR(CZ) GA13-20433S
Institucionální podpora: RVO:67985556
Klíčová slova: Optimal control * Nonlinear systems * Fermentation process * Gradient method optimization * Antibiotics production
Kód oboru RIV: BC - Teorie a systémy řízení
Impakt faktor: 1.997, rok: 2014
http://library.utia.cas.cz/separaty/2014/TR/celikovsky-0424718.pdf

Since their discovery, fermentation processes have gone along not only with the industrial beverages production and breweries, but since the times of Alexander Fleming, they have become a crucial part of the health care due to antibiotics production. However, complicated dynamics and strong nonlinearities cause that the production with the use of linear control methods achieves only suboptimal yields. From the variety of nonlinear approaches, gradient method has proved the ability to handle these issues—nevertheless, its potential in the field of fermentation processes has not been revealed completely. This paper describes constant vaporization control strategy based on a double-input optimization approach with a successful reduction to a single-input optimization task. To accomplish this, model structure used in the previous work is modified so that it corresponds with the new optimization strategy. Furthermore, choice of search step is explored and various alternatives are evaluated and compared.
Trvalý link: http://hdl.handle.net/11104/0230906