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Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
- 1.0423094 - ÚEB 2014 RIV FR eng J - Článek v odborném periodiku
Imramovský, A. - Jorda, Radek - Pauk, K. - Řezníčková, Eva - Dušek, J. - Hanousek, J. - Kryštof, Vladimír
Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.
European Journal of Medicinal Chemistry. Roč. 68, č. 2013 (2013), s. 253-259. ISSN 0223-5234. E-ISSN 1768-3254
Grant CEP: GA ČR GAP305/12/0783; GA ČR GA301/08/1649
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Diamides * Apoptosis * Cytotoxicity
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.432, rok: 2013
Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage.
Trvalý link: http://hdl.handle.net/11104/0229347
Název souboru Staženo Velikost Komentář Verze Přístup 2013_Imramovsky_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_253.pdf 0 729.5 KB Jiná povolen
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