DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation

0422698 - FZÚ 2014 RIV US eng A - Abstrakt
Kratochvílová, Irena - Sychrovský, Vladimír - Páv, Ondřej - Vala, M.
DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation.
Biophysical Journal. Cell Press. Roč. 104, č. 2 (2013), 424A-424A. ISSN 0006-3495. E-ISSN 1542-0086.
[57th Annual Meeting of the Biophysical-Society. 02.02.2013-06.02.2013, Philadelphia]
Grant CEP: GA TA ČR TA01011165; GA ČR(CZ) GAP304/10/1951
Institucionální podpora: RVO:68378271 ; RVO:61388963
Klíčová slova: oligonucleotides charge transfer * Hg incorporated DNA duplexes
Kód oboru RIV: BO - Biofyzika
http://adsabs.harvard.edu/abs/2013BpJ...104..424K

In this work experimental and theoretical approaches have been combined for unique study and comparison of charge transfer efficiency in standard and modified (Hg incorporated) DNA duplexes and DNA/RNA hybrids. Specific mechanism proposed to account for the on-chain oligonucleotide charge transport is based on polaron formation-charge is transported coherently by long-distance tunneling (superexchange). A key parameter in this approach is how the bridge orbitals of the intervening DNA bases couple the charge donor and acceptor - this is strongly controlled by specific oligomeres structures and conformation. The RNA/DNA system flexibility also improves the conditions for polaron creation and thus may facilitate rapid (coherent) charge transport in the DNA/RNA hybrids.
Trvalý link: http://hdl.handle.net/11104/0228849