Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats

0422612 - FGÚ 2014 RIV CZ eng J - Článek v odborném periodiku
Brožíčková, Carole - Otáhal, Jakub
Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats.
Physiological Research. Roč. 62, Suppl.1 (2013), S57-S66. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GAP303/10/0999; GA ČR(CZ) GPP304/11/P386; GA ČR(CZ) GBP304/12/G069
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: cerebral hemodynamic response * brain excitability * neuronal nitric oxide synthase * 7-nitroindazole * rat
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.487, rok: 2013

We examined neurovascular coupling in rat sensorimotor cortex in response to transcallosal stimulation under nNOS inhibition by 7-NI. Although 7-NI did not significantly affect basal cerebral blood flow and cortical excitability, hemodynamic responses to the transcallosal stimulation were diminished implicating a role of nNOS in neurovascular coupling. Our findings demonstrate that NO contributes to the hemodynamic response to brain activation
Trvalý link: http://hdl.handle.net/11104/0228876