Quantitative Contrast-Enhaced Ultrasound Comparsion Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease

0421683 - ÚPT 2014 RIV US eng J - Článek v odborném periodiku
Nylund, K. - Jiřík, Radovan - Mézl, M. - Leh, S. - Hausken, T. - Pfeffer, F. - Odegaard, S. - Taxt, T. - Gilja, O.H.
Quantitative Contrast-Enhaced Ultrasound Comparsion Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease.
Ultrasound in Medicine and Biology. Roč. 39, č. 7 (2013), s. 1197-1206. ISSN 0301-5629. E-ISSN 1879-291X
Grant CEP: GA ČR GAP102/12/2380
Institucionální podpora: RVO:68081731
Klíčová slova: Crohn's disease * Inflammatory bowel disease * Intestinal blood flow * Ultrasonography
Kód oboru RIV: FS - Lékařská zařízení, přístroje a vybavení
Impakt faktor: 2.099, rok: 2013

The aim of this study was to determine whether there are differences in absolute blood flow between patients with Crohn's disease with inflammation or fibrosis using contrast-enhanced ultrasound. Eighteen patients with fibrotic disease and 19 patients with inflammation were examined. Video sequences of contrast data were analyzed using a pharmacokinetic model to extract the arterial input and tissue residue functions with a custom software, enabling calculation of the absolute values for mean transit time, blood volume and flow. Feasibility of the examination was 89%. The fibrosis group had lower blood volume (0.9 vs. 3.4 mL per 100 mL tissue; p = 0.001) and flow (22.6 vs. 45.3 mL/min per 100 mL tissue; p = 0.003) compared with the inflammation group. There was no significant difference in mean transit time (3.9 vs. 5.5 s). In conclusion, absolute perfusion measurement in the gastrointestinal wall using contrast-enhanced ultrasound is feasible. There seems to be reduced blood volume and blood flow in patients with fibrotic disease.
Trvalý link: http://hdl.handle.net/11104/0227972