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Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice
- 1.0421314 - MBÚ 2014 RIV US eng J - Článek v odborném periodiku
Klimešová, Klára - Kverka, Miloslav - Zákostelská, Zuzana - Hudcovic, Tomáš - Hrnčíř, Tomáš - Štěpánková, Renata - Rossmann, Pavel - Rídl, Jakub - Kostovčík, Martin - Mrázek, Jakub - Kopečný, Jan - Kobayashi, K. - Tlaskalová-Hogenová, Helena
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Inflammatory Bowel Diseases. Roč. 19, č. 6 (2013), s. 1266-1277. ISSN 1078-0998. E-ISSN 1536-4844
Grant CEP: GA ČR(CZ) GAP304/11/1252; GA ČR GA303/08/0367; GA ČR GAP303/12/0535
Institucionální podpora: RVO:61388971 ; RVO:68378050 ; RVO:67985904
Klíčová slova: cancer in IBD * mucosal immunity * colorectal cancer
Kód oboru RIV: EC - Imunologie; CE - Biochemie (UMG-J); EE - Mikrobiologie, virologie (UZFG-Y)
Impakt faktor: 5.475, rok: 2013
Microbial sensing by Toll-like receptors (TLR) and its negative regulation have an important role in the pathogenesis of inflammation-related cancer. In this study, we investigated the role of negative regulation of Toll-like receptors signaling and gut microbiota in the development of colitis-associated cancer in mouse model. We conclude that gut microbiota promotes tumorigenesis by increasing the exposure of gut epithelium to carcinogens and that IRAK-M-negative regulation is essential for colon cancer resistance even in conditions of altered microbiota. Therefore, gut microbiota and its metabolic activity could be potential targets for colitis-associated cancer therapy
Trvalý link: http://hdl.handle.net/11104/0227669
Počet záznamů: 1