A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

0421240 - BC 2014 RIV CH eng J - Článek v odborném periodiku
Sakhon, O. S. - Severo, M. S. - Kotsyfakis, Michalis - Pedra, J. H. F.
A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva.
Frontiers in Microbiology. Roč. 4, OCT 2013 (2013), a308. ISSN 1664-302X. E-ISSN 1664-302X
Institucionální podpora: RVO:60077344
Klíčová slova: nod-like receptors * inflammasome * vector-borne pathogens * vector-borne diseases * arthropod saliva * salivary proteins
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.941, rok: 2013

Arthropod saliva possesses anti-hemostatic, anesthetic, and anti-inflammatory properties that facilitate feeding and, inadvertently, dissemination of pathogens. Vector-borne diseases caused by these pathogens affect millions of people each year. Many studies address the impact of arthropod salivary proteins on various immunological components. However, whether and how arthropod saliva counters Nod-like (NLR) sensing remains elusive. NLRs are innate immune pattern recognition molecules involved in detecting microbial molecules and danger signals. Nod1/2 signaling results in activation of the nuclear factor-κB and the mitogen-activated protein kinase pathways. Caspase-1 NLRs regulate the inflammasome- a protein scaffold that governs the maturation of interleukin (IL)-1β and IL-18. Recently, several vector-borne pathogens have been shown to induce NLR activation in immune cells. Here, we provide a brief overview of NLR signaling and discuss clinically relevant vector-borne pathogens recognized by NLR pathways. We also elaborate on possible anti-inflammatory effects of arthropod saliva on NLR signaling and microbial pathogenesis for the purpose of exchanging research perspectives.
Trvalý link: http://hdl.handle.net/11104/0227644