Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels

0420960 - FGÚ 2014 RIV GB eng J - Článek v odborném periodiku
Neckář, Jan - Borchert, Gudrun H. - Hloušková, P. - Míčová, P. - Nováková, O. - Novák, F. - Hroch, M. - Papoušek, František - Ošťádal, Bohuslav - Kolář, František
Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels.
Current Pharmaceutical Design. Roč. 19, č. 39 (2013), s. 6880-6889. ISSN 1381-6128. E-ISSN 1873-4286
Grant CEP: GA AV ČR(CZ) IAAX01110901; GA ČR(CZ) GA305/07/0875; GA ČR(CZ) GAP303/12/1162
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: chronic continuous hypoxia * reoxygenation * ischemia/reperfusion * myocardial infarction * potassium channels * oxidative stress
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 3.288, rok: 2013

The purpose of the study was to assess the impact of brief daily reoxygenation during adaptation to chronic continuous hypoxia on protective cardiac phenotype. The results suggest that chronic continuous hypoxia is cardioprotective and brief daily reoxygenation blunts its salutary effects, possibly by a mechanism involving oxidative stress and attenuation of the activation of mitochondrial BKCa channels
Trvalý link: http://hdl.handle.net/11104/0227483