First results on cell irradiation with laser-driven protons on the TARANIS system

0420820 - FZÚ 2014 RIV US eng C - Konferenční příspěvek (zahraniční konf.)
Kar, S. - Doria, D. - Kakolee, K.F. - Prasad, R. - Litt, S. - Ahmed, H. - Nersisyan, G. - Lewis, C. - Zepf, M. - Borghesi, Marco - Schettino, G. - Prise, K.M. - Fiorini, F. - Kirby, D. - Green, S. - Jeynes, J.C.G. - Merchant, M.J. - Kirkby, K.J.
First results on cell irradiation with laser-driven protons on the TARANIS system.
2nd ELIMED Workshop and Panel. Melville: AIP, 2013 - (Margarone, D.; Cirrone, P.; Cuttone, G.; Korn, G.), s. 87-89. AIP Conference Proceedings, 1546. ISBN 978-0-7354-1171-5.
[MEDical and Multidisciplinary Applications at ELI (ELIMED) Workshop and Panel /2./. Catania (IT), 18.10.2012-19.10.2012]
Grant CEP: GA MŠMT ED1.1.00/02.0061; GA MŠMT EE.2.3.20.0087
Grant ostatní: ELI Beamlines(XE) CZ.1.05/1.1.00/02.0061; OP VK 2 LaserGen(XE) CZ.1.07/2.3.00/20.0087
Institucionální podpora: RVO:68378271
Klíčová slova: TARANIS Terawatt laser * proton irradiation * radiobiological studies * cells
Kód oboru RIV: BL - Fyzika plazmatu a výboje v plynech

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen’s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.
Trvalý link: http://hdl.handle.net/11104/0227309