Circulating Intracellular Cell Adhesion Molecule-1, Endothelin-1, and von Willebrand Factor-Markers of Endothelial Dysfunction in Uncomplicated Essential Hypertension: the Effect of Treatment with ACE Inhibitors

0404776 - UIVT-O 20020183 RIV GB eng J - Článek v odborném periodiku
Hlubocká, Z. - Umnerová, V. - Heller, S. - Peleška, Jan - Jindra, A. - Jáchymová, M. - Kvasnička, J. - Horký, K. - Aschermann, M.
Circulating Intracellular Cell Adhesion Molecule-1, Endothelin-1, and von Willebrand Factor-Markers of Endothelial Dysfunction in Uncomplicated Essential Hypertension: the Effect of Treatment with ACE Inhibitors.
Journal of Human Hypertension. Roč. 16, č. 8 (2002), s. 557-562. ISSN 0950-9240. E-ISSN 1476-5527
Grant CEP: GA MZd NA5615
Klíčová slova: soluble adhesion moleculs * von Willebrand factor * endothelin-1 * endothelial dysfunction
Kód oboru RIV: BB - Aplikovaná statistika, operační výzkum
Impakt faktor: 1.366, rok: 2002

Compared with controls the mild hypertensive subjects with no other risk factors for atherosclerosis had significantly higher levels of intercellular cell adhesion molecule (ICAM-1), von Willebrand factor and endothelin-1. Three-month treatment with quinapril led to a significant decrease of endothelin-1 and only to a trend toward a decrease in the other factors. Therefore, these factors may serve as markers of endothelial damage and ACE inhibitors may have a beneficial effect on endothelial dysfunction.
Trvalý link: http://hdl.handle.net/11104/0125010