Two faces of microbiota in inflammatory and autoimmune diseases: triggers and drugs

0399835 - MBÚ 2014 RIV DK eng J - Článek v odborném periodiku
Kverka, Miloslav - Tlaskalová-Hogenová, Helena
Two faces of microbiota in inflammatory and autoimmune diseases: triggers and drugs.
Acta Pathologica Microbiologica et Immunologica Scandinavica. Roč. 121, č. 5 (2013), s. 403-421. ISSN 0903-4641. E-ISSN 1600-0463
Grant CEP: GA ČR GAP303/12/0535; GA ČR(CZ) GAP304/11/1252; GA MZd(CZ) NT13483
Institucionální podpora: RVO:61388971
Klíčová slova: Inflammation * autoimmunity * probiotics
Kód oboru RIV: EC - Imunologie
Impakt faktor: 1.922, rok: 2013

The prevalence of chronic autoimmune and inflammatory diseases, such as inflammatory bowel disease, allergies, or rheumatic diseases, is steadily increasing in developed countries. This increase is probably accelerated by environmental factors, such as decrease in infectious burden or changes in food processing. These lifestyle changes then strongly influence the strongest stimulus for the immune system commensal microbiota. Despite the differences in the affected organ, the immune-mediated diseases have one or more factors in common microbe either as a trigger or as a protector, mucosal barrier dysfunction, and dysregulation of the immune system. The core questions, which microbes are involved and how these diseases can be cured or even prevented still remain unsolved. Powered by the recent progress in technology, by new insights into the function of immune system, by advances in microbiome research, and extended use of gnotobiological techniques, these mechanisms are now being unravelled and new therapeutic possibilities are emerging. To secure their niche, the microbes devised many ingenious ways, how to dampen the inflammation. Nonpathogenic microorganisms or microbial components isolated from probiotic, commensal or even pathogenic microbes could be, therefore, used to interfere with the pathogenetic mechanisms of immune-mediated diseases
Trvalý link: http://hdl.handle.net/11104/0227079