Biphasic equilibrium dialysis of poly(N-isopropyl acrylamide) nanogels synthesized at decreased temperatures for targeted delivery of thermosensitive bioactives

0399348 - ÚMCH 2014 RIV US eng J - Článek v odborném periodiku
Musial, W. - Michálek, Jiří - Pluta, J. - Jaromin, A. - Pietka-Ottlik, M. - Přádný, Martin
Biphasic equilibrium dialysis of poly(N-isopropyl acrylamide) nanogels synthesized at decreased temperatures for targeted delivery of thermosensitive bioactives.
International Journal of Polymer Science. Roč. 2013, č. 2013 (2013), 925235_1-925235_9. ISSN 1687-9422. E-ISSN 1687-9430
Institucionální podpora: RVO:61389013
Klíčová slova: hydrogel nanoparticles * thermosensitive nanogel * poly-N-isopropyl acrylamide
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 1.322, rok: 2013

Hydrogel nanoparticles, referred to also as nanogels, are of special interest for medical and pharmaceutical applications. Due to small size in the range below the diameter of the capillaries, they are proposed as drug delivery carriers. The aim of the study was to estimate the influence of composition and reaction conditions during synthesis of poly-N-isopropyl acrylamide cross-linked by polyethylene glycol diacrylate on the purification rates of the polymer. Six types of thermosensitive nanogels were prepared by surfactant-free dispersion polymerization and assessed in terms of process yield, composition, and size at temperatures below and over volume phase temperature. During the diffusion of impurities, in the course of dialysis, assessed by the conductometric method, the remarkable influence of temperature and initiator concentration on the process was revealed.The release rates varied in the range between 9.63 . 10−2 and 1.39 . 10−1 h−1 in the first stage of the process, whereas in the second stage they were between 2.09 . 10−2 and 6.28 . 10−2 h−1.The evaluated time to obtain acceptable purity of the preparation was estimated to be in the range of 18 days. More detailed research should be directed towards the influence of the structure of obtained material on the purification process.
Trvalý link: http://hdl.handle.net/11104/0227123