Feasibility study of direct cyclotron production of 227-Th

0399087 - ÚJF 2014 US eng A - Abstrakt
Kozempel, J. - Vlk, M. - Mičolová, P. - Lebeda, Ondřej - Moša, M. - Morgenstern, A.
Feasibility study of direct cyclotron production of 227-Th.
European Journal of Nuclear Medicine and Molecular Imaging. Springer. Roč. 40, 2 Supplement (2013), S191-S192. ISSN 1619-7070. E-ISSN 1619-7089.
[Annual Congress of the European Association of Nuclear Medicine (EANM). 19.10.2013-23.10.2013, Lyon]
Institucionální podpora: RVO:61389005
Klíčová slova: 227Th * alternative method of production 227Th * cyclotron U-120M
Kód oboru RIV: BG - Jaderná, atomová a mol. fyzika, urychlovače

Aim Alpha emitting radiometals are promising tools for cancer treatment. One of them is 223Ra (half-life of 11.4 days) together with its mother nuclide, 227Th (half-life of 18.7 days).These nuclides can be obtained from 227Ac/227Th/223Ra generator produced via 226Ra(n,γ)227Ra/227Ac reaction using nuclear reactor. This fact puts, however, high requirements on radiation stability of such a generator. Aim of this study was to develop alternative method for direct cyclotron production of 227Th via 226Ra(α,3n) reaction. Methods Cross-sections of the 226Ra(α,3n) reaction were adopted from TENDL-2012 library based on TALYS nuclear model code. Using these data, thick target yields of this reaction were calculated. Experimental verification of the predicted values was performed on a U-120M isochronous cyclotron of the Nuclear Physics Institute of the Academy of Science of the Czech Republic by irradiating single thin 226Ra targets.
Trvalý link: http://hdl.handle.net/11104/0226479