Cobalt zinc ferrite nanoparticles – a suitable tool for magnetic cell labeling

0399026 - FZÚ 2014 DE eng A - Abstrakt
Jendelová, Pavla - Novotná, Božena - Turnovcová, Karolína - Žvátora, Pavel - Veverka, Miroslav - Bagryantseva, Yana - Herynek, V. - Syková, Eva
Cobalt zinc ferrite nanoparticles – a suitable tool for magnetic cell labeling.
Tthe Abstracts of the World Conference on Regenerative Medicine 2013. Leipzig: Fraunhofer Institute for Cell Therapy and Immunology, 2013. PP-137.
[World Conference on Regenerative Medicine 2013 /WCRM 2013/. 23.10.2013-25.10.2013, Leipzig]
Grant CEP: GA ČR(CZ) GAP304/12/1370; GA ČR GAP204/10/0035
Institucionální podpora: RVO:68378271 ; RVO:68378041
Klíčová slova: cobalt-zinc ferrite * cell labeling * magnetic resonance imaging * genotoxicity
Kód oboru RIV: FJ - Chirurgie vč. transplantologie
http://wcrm.future-science-group.com/pdfs/PP-137.pdf#search=%22magnetic%20cell%22

To monitor the fate of transplanted cells within an organism, several non-invasive techniques have been introduced, including magnetic resonance imaging (MRI) of cells labeled with a contrast agent prior to grafting. Our previous study demonstrated a severe oxidative injury to lipids, proteins and the DNA of human bone marrow mesenchymal stem cells as a result of their labeling with superparamagnetic iron oxide nanoparticles (SPIONs). In searching for new contrast agents and magnetic cell labels, we prepared and tested a contrast agent based not only on Fe, but also on Co and Zn [cobalt zinc ferrite Co0.5Zn0.5Fe2O4+γ (CZF)] with a core encapsulated by amorphous silica.
Trvalý link: http://hdl.handle.net/11104/0226411