Effect of Block of alpha(1)-adrenoceptors on Overall Motor Activity but not on Spatial Cognition in the Object-Position Recognition Task

0398817 - FGÚ 2014 RIV CZ eng J - Článek v odborném periodiku
Levčík, David - Stuchlík, Aleš - Klement, Daniel
Effect of Block of alpha(1)-adrenoceptors on Overall Motor Activity but not on Spatial Cognition in the Object-Position Recognition Task.
Physiological Research. Roč. 62, č. 5 (2013), s. 561-567. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GBP304/12/G069; GA MZd(CZ) NT13386
Grant ostatní: Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M200111204
Institucionální podpora: RVO:67985823
Klíčová slova: recognition * prazosin * rat * learning
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.487, rok: 2013

The present study investigated the effect of prazosin on the modulation of overall motor activity and on cognitive performance in a spatial operant task called object-position recognition task, where operant behavior (lever pressing) was controlled by spatial stimuli displayed on a computer screen. This task has been previously showed to be hippocampus-dependent. Pre-test injection of prazosin at the dose of 3 mg/kg decreased the responding rate, while it did not affect the recognition of object's position. In conclusion, we validated the new cognitive test with a drug with known pharmacological effects on behavior and confirmed the depressant effect of prazosin on activity and no effect on retrieval of memory
Trvalý link: http://hdl.handle.net/11104/0226191