The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage

0398231 - ÚEM 2015 RIV ES eng J - Článek v odborném periodiku
Čejková, Jitka - Olmiere, C. - Čejka, Čestmír - Trošan, Peter - Holáň, Vladimír
The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20) – a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage.
Histology and Histopathology. Roč. 29, č. 4 (2014), s. 457-478. ISSN 0213-3911. E-ISSN 1699-5848
Grant CEP: GA ČR GAP304/11/0653
Výzkumný záměr: CEZ:AV0Z50390512
Institucionální podpora: RVO:68378041
Klíčová slova: RGTA * alkali injury * corneal healing
Kód oboru RIV: FF - ORL, oftalmologie, stomatologie
Impakt faktor: 2.096, rok: 2014

Heparan sulfate mimicking regeneration agent (RGTA) enabled the healing of the rabbit cornea, injured with highly concentrated alkali. When RGTA was applied by dropping on the damaged cornea early after the injury, it highly suppresed the development of corneal ulcerative processes. When the damaged cornea was topically treated with RGTA later after the injury – during the occurence of corneal ulcers, it healed majority of them. The healing of the alkali-injured cornea by RGTA took place due to the reduction of proteolytic, oxidative and nitrosative damage. key words (3): RGTA, alkali injury, corneal healing
Trvalý link: http://hdl.handle.net/11104/0233917