Enantioseparation of newly synthesized acyclic nucleoside phosphonates-based antivirals by capillary electrophoresis using cyclodextrins as chiral selectors

0398135 - ÚOCHB 2014 SK eng C - Konferenční příspěvek (zahraniční konf.)
Šolínová, Veronika - Kaiser, Martin Maxmilian - Lukáč, Miloš - Janeba, Zlatko - Kašička, Václav
Enantioseparation of newly synthesized acyclic nucleoside phosphonates-based antivirals by capillary electrophoresis using cyclodextrins as chiral selectors.
Analytické metódy a zdravie človeka. 19. medzinárodná konferencia. Bratislava: Slovenská vákuová spoločnosť, 2013 - (Bodor, R.; Okenicová, L.; Staňová, A.), s. 245-247. ISBN 978-80-971179-1-7.
[Analytické metódy a zdravie človeka. Medzinárodná konferencia /19./. Rajecké Teplice (SK), 24.06.2013-27.06.2013]
Grant CEP: GA ČR(CZ) GAP206/12/0453; GA ČR GA13-17224S; GA MV VG20102015046
Grant ostatní: AV ČR CSIC(CZ) 2008CZ0019
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates * chiral analysis * capillary electrophoresis
Kód oboru RIV: CB - Analytická chemie, separace

Capillary electrophoresis (CE) methods were developed for chiral separation and enantiopurity control of six newly synthesized R,S-enantiomers of acyclic nucleoside phosphonates (ANPs)-based potential antivirals containing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid moiety, 2 (phosphonomethoxy)propanoic acid or its diisopropyl derivative as side chains of adenine, guanine, diaminopurine, uracil and 5-bromouracil nucleobases, using sodium tetraborate, pH 9.6-10.3, or Tris-phosphate, pH 2.2, as background electrolytes and beta-cyclodextrin or quaternary-ammonium-beta-cyclodextrin as chiral selectors.
Trvalý link: http://hdl.handle.net/11104/0225703