Caspase-7 participates in differentiation of cells forming dental hard tissues

0397909 - ÚŽFG 2014 RIV JP eng J - Článek v odborném periodiku
Matalová, Eva - Lesot, H. - Švandová, Eva - Vanden Berghe, T. - Sharpe, P. T. - Healy, C. - Vandenabeele, P. - Tucker, A. S.
Caspase-7 participates in differentiation of cells forming dental hard tissues.
Development Growth & Differentiation. Roč. 55, č. 5 (2013), s. 615-621. ISSN 0012-1592. E-ISSN 1440-169X
Grant CEP: GA ČR GAP304/11/1418
Grant ostatní: GA ČR(CZ) GAP502/12/1285
Program: GA
Institucionální podpora: RVO:67985904
Klíčová slova: ameloblast * apoptosis * caspase
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.178, rok: 2013

Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
Trvalý link: http://hdl.handle.net/11104/0225532