Common and small molecules as the ultimate regulatory and effector mediators of antigen-specific transplantation reactions

0397908 - ÚEM 2014 RIV HK eng J - Článek v odborném periodiku
Holáň, Vladimír - Krulová, Magdaléna
Common and small molecules as the ultimate regulatory and effector mediators of antigen-specific transplantation reactions.
World journal of transplantation. Roč. 3, č. 4 (2013), s. 54-61. ISSN 2220-3230
Grant CEP: GA ČR GAP304/11/0653; GA ČR(CZ) GAP301/11/1568; GA MZd NT14102
Institucionální podpora: RVO:68378041
Klíčová slova: immunoregulation * graft rejection * tolerance
Kód oboru RIV: EC - Imunologie

The authors suggest that the functioning of common and small molecules with enzymatic activities, such as iNOS, arginase, HO-1 or IDO, the bioavailability of their suibstrates (L-arginin, tryptophan) and the action of their small gaseous products (NO, CO) can be the ultimate mechanisms responsible for the effector immune reactios. Thus, in spite of the high immunological specificity of the immune system, the small and common molecules are the important effector players ensuring the specidfic immune reactions.
Trvalý link: http://hdl.handle.net/11104/0228295