Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells

0397649 - ÚEM 2014 RIV GB eng J - Článek v odborném periodiku
Rampichová, Michala - Chvojka, J. - Buzgo, Matej - Prosecká, Eva - Mikeš, P. - Vysloužilová, L. - Tvrdík, D. - Kochová, P. - Gregor, T. - Lukáš, D. - Amler, Evžen
Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells.
Cell Proliferation. Roč. 46, č. 1 (2013), s. 23-37. ISSN 0960-7722. E-ISSN 1365-2184
Grant CEP: GA AV ČR(CZ) IAA500390702; GA ČR GAP304/10/1307
Grant ostatní: GA MZd(CZ) NT12156; GA MŠk(CZ) ME10145; GA MŠk(CZ) CZ.1.05/2.1.00/03.0088; GA MŠk(CZ) CZ.1.05/1.1.00/02.0090; GA UK(CZ) 96610; GA UK(CZ) 97110; GA UK(CZ) 330611; GA UK(CZ) 384311; GA UK(CZ) 164010; GA UK(CZ) 626011
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Klíčová slova: mesenchymal stem cell * polycaprolactone * bone tissue engineering
Kód oboru RIV: FP - Ostatní lékařské obory
Impakt faktor: 3.280, rok: 2013

Three-dimensional poly (ε-caprolactone) (PCL) nanofibrous scaffolds were prepared and tested for the seeding, proliferation, differentiation, and migration of mesenchymal stem cell (MSCs). Compared to 2D PCL nanofibres, 3D nanofibres showed better biomechanical properties, cell proliferation and osteogenic differentiation. Moreover, larger pores in 3D PCL enabled infiltration of cells throughout nanofibrous layers. Thus, proposed 3D structure of the nanofibre layer can find broad applications in tissue engineering and regenerative medicine.
Trvalý link: http://hdl.handle.net/11104/0225270