Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles

0397537 - FGÚ 2014 RIV US eng J - Článek v odborném periodiku
Sládek, Martin - Sumová, Alena
Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles.
PLoS ONE. Roč. 8, č. 10 (2013), e77010. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR(CZ) GPP305/10/P244; GA ČR(CZ) GAP303/11/0668
Institucionální podpora: RVO:67985823
Klíčová slova: circadian rhythms * temperature * entrainment * SHR * fibroblasts * phase response curve
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.534, rok: 2013

We showed that two consecutive square-wave temperature cycles with amplitudes of 2.5°C are with similar efficiency able to restart damped oscillations and entrain the circadian clock in fibroblasts derived from both spontaneously hypertensive rat and control Wistar rat. We described phase response curves to temperature cycles for fibroblast clock from both strains and concluded that despite slight resistance of SHR cells to temperature entrainment, the overall effect is too weak to be responsible for SHR circadian phenotype in vivo
Trvalý link: http://hdl.handle.net/11104/0225203