Azahelicene Superbases as MAILD Matrices for Acidic Analytes

0397464 - ÚOCHB 2014 RIV DE eng J - Článek v odborném periodiku
Napagoda, M. - Rulíšek, Lubomír - Jančařík, Andrej - Klívar, Jiří - Šámal, Michal - Stará, Irena G. - Starý, Ivo - Šolínová, Veronika - Kašička, Václav - Svatoš, Aleš
Azahelicene Superbases as MAILD Matrices for Acidic Analytes.
ChemPlusChem. Roč. 78, č. 9 (2013), s. 937-942. ISSN 2192-6506. E-ISSN 2192-6506
Grant CEP: GA ČR GA203/09/1766; GA ČR(CZ) GAP206/12/0453; GA AV ČR IAA400550916
Institucionální podpora: RVO:61388963
Klíčová slova: azahelicene superbases * MAILD-MS matrix * acidic analytes * matrix isolation * metabolomics
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.242, rok: 2013

1,14-Diaza[5]helicene can serve as a new, efficient MAILD matrix, outperforming other bases such as DMAN, and is highly suitable for high-throughput metabolomics analysis. Superiority of this compound stemmed from the constructive interplay of its high basicity, ability to absorb energy of UV-light laser pulses, and resistance to fragmentation and desorption. Experimental and computational data led us to discover a rationale for the ionisation processprocess: there is a correlation between the basicity (and proton-sponge character) of matrices and their efficacy in MAILD-MS.
Trvalý link: http://hdl.handle.net/11104/0225128