The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects

0397075 - ÚEM 2014 RIV DE eng J - Článek v odborném periodiku
Vaněček, Václav - Klíma, K. - Kohout, A. - Foltán, R. - Jiroušek, Ondřej - Šedý, Jiří - Štulík, J. - Syková, Eva - Jendelová, Pavla
The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects.
European Spine Journal. Roč. 22, č. 12 (2013), s. 2777-2786. ISSN 0940-6719. E-ISSN 1432-0932
Grant CEP: GA ČR GAP304/10/0320; GA MZd(CZ) NT13477
Institucionální podpora: RVO:68378041 ; RVO:68378297 ; RVO:67985823
Klíčová slova: vertebral body defect * mesenchymal stem cells * hydroxyapatite scaffold
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy; FI - Traumatologie, ortopedie (UTAM-F); FI - Traumatologie, ortopedie (FGU-C)
Impakt faktor: 2.473, rok: 2013

The safety and efficacy of a composite bioartificial graft based on a hydroxyapatite bone scaffold (CEM-OSTETIC®) combined with human mesenchymal stem cells (MSCs) was evaluated in a rat model of vertebral body defects. Significant effect on the formation of new bone tissue in the defect a reduced inflammatory reaction was detected after combination of 5 mil MSC and scaffold. No substantial pathological changes or tumor formation after graft implantation were observed.
Trvalý link: http://hdl.handle.net/11104/0227057