Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis

0396937 - FGÚ 2014 RIV NL eng J - Článek v odborném periodiku
De la Rosa, A. J. - Domínguez, J. N. - Sedmera, D. - Šaňková, Barbora - Hove-Madsen, L. - Franco, D. - Aránega, A. E.
Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.
Cardiovascular Research. Roč. 98, č. 3 (2013), s. 504-514. ISSN 0008-6363. E-ISSN 1755-3245
Grant CEP: GA ČR(CZ) GA304/08/0615; GA ČR(CZ) GAP302/11/1308; GA ČR(CZ) GD204/09/H084; GA ČR(CZ) GA13-12412S
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: ion channels * Long-QT syndrome * sudden death * cardiac hypertrophy
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 5.808, rok: 2013

Early sodium channel remodelling secondary to IKs blockage in a mouse model of LQTS leading to morphological and functional anomalies in the developing VCS and cardiac hypertrophy. These results provide new insights into the mechanisms underlying foetal and neonatal cardiac electrophysiological disorders, which might help understand how molecular, functional, and morphological alterations are linked to clinical pathologies such as cardiac congenital anomalies, arrhythmias, and perinatal sudden death
Trvalý link: http://hdl.handle.net/11104/0224587