Počet záznamů: 1
Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164
- 1.0396909 - FGÚ 2014 RIV US eng J - Článek v odborném periodiku
Kuda, Ondřej - Pietka, T. A. - Demianova, Zuzana - Kudová, Eva - Cvačka, Josef - Kopecký, Jan - Abumrad, N. A.
Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164.
Journal of Biological Chemistry. Roč. 288, č. 22 (2013), s. 15547-15555. ISSN 0021-9258. E-ISSN 1083-351X
Grant CEP: GA MŠMT(CZ) 7E12073; GA ČR(CZ) GP13-04449P
Institucionální podpora: RVO:67985823 ; RVO:61388963
Klíčová slova: CD36 * sulfo-N-succinimidyl oleate * mass spectrometry
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa; CE - Biochemie (UOCHB-X)
Impakt faktor: 4.600, rok: 2013
Mechanism of CD36 inhibition by sulfo-N-succinimidyl oleate (SSO) was explored using mass spectrometry and mutagenesis. SSO binds lysine 164 and inhibits uptake of fatty acids and oxLDL. Lysine 164 is important for CD36-mediated fatty acid uptake and Ca2+signaling. Fatty acids and oxLDL bind to the same site within a hydrophobic pocket of CD36 shared by several lipid ligands
Trvalý link: http://hdl.handle.net/11104/0224576
Počet záznamů: 1