Počet záznamů: 1
Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats
- 1.0396903 - FGÚ 2014 RIV GB eng J - Článek v odborném periodiku
Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Petrová, M. - Líšková, Silvia - Karen, Petr - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats.
Journal of Hypertension. Roč. 31, č. 10 (2013), s. 2025-2035. ISSN 0263-6352. E-ISSN 1473-5598
Grant CEP: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: Ca2+ influx * nifedipine * RhoA/Rho kinase * fasudil * sympathetic vasoconstriction
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 4.222, rok: 2013
The participation of calcium entry and calcium sensitization in the control of blood pressure (BP) and vascular contraction was studied in SHR and normotensive WKY rats. Ca2+ sensitization mediated by RhoA/Rho kinase pathway is attenuated in SHR compared to normotensive WKY rats. This might be a part of the compensation for enhanced Ca2+ entry through L-VDCC in genetic hypertension
Trvalý link: http://hdl.handle.net/11104/0224624
Počet záznamů: 1