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The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice

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    0396572 - ÚEM 2014 RIV IE eng J - Článek v odborném periodiku
    Popelář, Jiří - Rybalko, Natalia - Burianová, Jana - Schwaller, B. - Syka, Josef
    The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice.
    Neuroscience Letters. Roč. 553, October (2013), s. 216-220. ISSN 0304-3940. E-ISSN 1872-7972
    Grant CEP: GA ČR(CZ) GAP304/12/1342; GA MŠMT(CZ) EE2.3.30.0018
    Grant ostatní: GA MŠk(CZ) ED1.1.00/02.0109
    Program: ED
    Institucionální podpora: RVO:68378041
    Klíčová slova: parvalbumin-deficient mice * acoustic startle reflex * prepulse inhibition
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.055, rok: 2013

    The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-) mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effect of PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific changes in neuronal circuits, mainly inhibitory, in the auditory centers in PV-deficient mice.
    Trvalý link: http://hdl.handle.net/11104/0224331

     
     
Počet záznamů: 1  

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