Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties

0396383 - ÚOCHB 2014 RIV IT eng J - Článek v odborném periodiku
Harmatha, Juraj - Buděšínský, Miloš - Vokáč, Karel - Kostecká, Petra - Kmoníčková, Eva - Zídek, Zdeněk
Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties.
Fitoterapia. Roč. 89, September (2013), s. 157-166. ISSN 0367-326X. E-ISSN 1873-6971
Grant CEP: GA ČR GA305/07/0061
Institucionální podpora: RVO:61388963 ; RVO:68378041
Klíčová slova: Laser trilobum * nitric oxide * trilobolide * thapsigargin * cytokine * sesquiterpene
Kód oboru RIV: CC - Organická chemie; FR - Farmakologie a lékárnická chemie (UEM-P)
Impakt faktor: 2.216, rok: 2013

Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide belong to the guaianolide type, and the third one, eudeslaserolide, to the biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor of germacranolide type (laserolide) are present in L. trilobum, as well as in the related Laserpitium species. Purposefully selected set of these native sesquiterpene lactones was tested for specific immunobiological properties. The obtained results demonstrate that trilobolide and its acetoxy analog are strong activators of cytokine secretion. On the contrary, the other L. trilobum and Laserpitium siler constituents are only very mild activators, or even inhibitors of the cytokine and nitric oxide production.
Trvalý link: http://hdl.handle.net/11104/0224219