Evc Regulates a Symmetrical Response to Shh Signaling in Molar Development

0396271 - ÚEM 2014 RIV US eng J - Článek v odborném periodiku
Nakatomi, M. - Hovořáková, Mária - Gritli-Linde, A. - Blair, H. J. - MacArthur, K. - Peterka, Miroslav - Lesot, H. - Peterková, Renata - Ruiz-Perez, V. L. - Goodship, J. A. - Peters, H.
Evc Regulates a Symmetrical Response to Shh Signaling in Molar Development.
Journal of Dental Research. Roč. 92, č. 3 (2013), s. 222-228. ISSN 0022-0345. E-ISSN 1544-0591
Grant CEP: GA ČR GA304/09/1579; GA ČR(CZ) GAP305/12/1766
Institucionální podpora: RVO:68378041
Klíčová slova: odontogenesis * organogenesis * embryonic and fetal development
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 4.144, rok: 2013

The observed growth abnormalities eventually manifest in first molar microdontia, disruption of molar segmentation and symmetry, root fusions, and delayed differentiation. Analysis of our data indicates that both spatially and temporally disrupted activities of the Shh pathway are the primary cause for the variable dental anomalies seen in patients with Ellis-van Creveld syndrome or Weyers acrodental dysostosis.
Trvalý link: http://hdl.handle.net/11104/0224108