Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

0395370 - ÚEM 2014 RIV NL eng J - Článek v odborném periodiku
Rössnerová, Andrea - Tulupová, Elena - Tabashidze, Nana - Schmuczerová, Jana - Dostál, Miroslav - Rössner ml., Pavel - Gmuender, H. - Šrám, Radim
Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 741-742, January (2013), s. 18-26. ISSN 0027-5107
Grant CEP: GA ČR GAP503/11/0084; GA ČR GA13-13458S; GA MŽP(CZ) SP/1B3/8/08
Institucionální podpora: RVO:68378041
Klíčová slova: 27K BeadChip * air pollution * bronchial asthma
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 4.440, rok: 2013

Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and a control Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels were observed. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life.
Trvalý link: http://hdl.handle.net/11104/0223403