Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols

0395359 - ÚEM 2014 RIV NL eng J - Článek v odborném periodiku
Topinka, Jan - Milcová, Alena - Schmuczerová, Jana - Kroužek, J. - Hovorka, J.
Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols.
Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Roč. 754, 1-2 (2013), s. 1-6. ISSN 1383-5718. E-ISSN 1879-3592
Grant CEP: GA ČR(CZ) GAP503/11/0142; GA ČR(CZ) GBP503/12/G147
Grant ostatní: MZP(CZ) SP/1A3/149/08
Institucionální podpora: RVO:68378041
Klíčová slova: Air pollution * Ultrafine particles * Carcinogenic PAHs
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 2.481, rok: 2013

Some studies suggest that genotoxic effect of combustion-related aerosols are induced by c-PAHs and their derivatives, which are part of the organic fraction of particulate matter (PM) in ambient air. The ultrafine organic fraction in PM is hypothesized to be the most important carrier of c-PAHs. To test this hypothesis, the distribution of c-PAHs in organic extracts (EOMs) was compared for four size fractions of ambient air aerosols. High volume aerosol samples were collected consecutively in four localities that differed in the level of environmental pollution. Interestingly, the results suggest that the fraction of ultrafine particles of various ambient-air samples is neither a major carrier of c-PAHs, nor a major inducer of their genotoxicity. This is important finding that is relevant to the toxicity and health effects of ultrafine particles, which are so extensively discussed these days.
Trvalý link: http://hdl.handle.net/11104/0223398