Počet záznamů: 1  

Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

  1. 1.
    0394792 - BFÚ 2014 RIV NL eng J - Článek v odborném periodiku
    Pekarová, Michaela - Kubala, Lukáš - Martíšková, Hana - Binó, Lucia - Twarogová, M. - Klinke, A. - Rudolph, T.K. - Kuchtová, Z. - Kolářová, Hana - Ambrožová, Gabriela - Kuchta, R. - Kadlec, J. - Lojek, Antonín
    Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression.
    European Journal of Pharmacology. Roč. 713, 1-3 (2013), s. 68-77. ISSN 0014-2999. E-ISSN 1879-0712
    Grant CEP: GA ČR(CZ) GP13-40882P
    Výzkumný záměr: CEZ:AV0Z50040702
    Institucionální podpora: RVO:68081707
    Klíčová slova: Macrophage * Methylarginine * Asymmetric dimethylarginine
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.684, rok: 2013

    Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced methylarginines, inhibitors for NO derived from macrophages and endothelial cells. Therefore, the aim of this study was to show the potential pharmacological intervention of methylarginines (N-G-methyl-L-arginine, L-NMMA; N-G, N-G'-dimethyl-L-arginine-symmetric dimethylarginine, SDMA; and N-G, N-G-dimethyl-L-arginine-asymmetric dimethylarginine, ADMA) in activation of murine peritoneal (RAW 264.7) and alveolar (MHS) macrophages with lipopolysaccharide from Gram-negative bacteria (LPS).
    Trvalý link: http://hdl.handle.net/11104/0222987

     
     
Počet záznamů: 1  

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