Počet záznamů: 1  

Preparation and Separation of Telechelic Carborane-Containing Poly(ethylene glycol)s

  1. 1.
    0394200 - ÚOCHB 2014 RIV DE eng J - Článek v odborném periodiku
    Matějíček, P. - Uchman, M. - Lepšík, Martin - Srnec, Martin - Zedník, J. - Kozlík, P. - Kalíková, K.
    Preparation and Separation of Telechelic Carborane-Containing Poly(ethylene glycol)s.
    ChemPlusChem. Roč. 78, č. 6 (2013), s. 528-535. ISSN 2192-6506. E-ISSN 2192-6506
    Grant CEP: GA AV ČR IAAX00320901
    Grant ostatní: GA ČR(CZ) GPP208/12/P236
    Institucionální podpora: RVO:61388963
    Klíčová slova: carboranes * click chemistry * poly(ethylene glycol) * quantum chemistry * reaction mechanisms
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 3.242, rok: 2013

    In the search for biocompatible amphiphilic polymers, carborane-substituted poly(ethylene glycol)s (PEGs) have been prepared in either a linear mono- and disubstituted or starlike tetrasubstituted shape. The reaction was performed by UV-initiated radical thiol/ene coupling of para-carborane-1-thiol to the corresponding allyl-terminated PEG, diallyl-terminated PEG, and tetraallyl-terminated starlike PEG. After the optimization of reaction conditions, the products were characterized by standard spectroscopic and chromatographic techniques. It was also demonstrated that it is possible to separate individual species differing in the number of attached carborane moieties by means of HPLC on an (R,S)-hydroxypropyl-modified -cyclodextrin column. To understand the mechanism in atomistic and energetic detail, this reaction was examined by means of quantum mechanics (QM) calculations. Further, because the carborane cluster is hypothesized to behave as a radical trap, QM calculations of the stability of various radicals derived from all the stable carboranethiol isomers with thiol group attached either to carbon or boron atoms were performed. The newly prepared carborane PEGs have an amphiphilic structure and might therefore be utilized in bio-oriented applications.
    Trvalý link: http://hdl.handle.net/11104/0222497

     
     
Počet záznamů: 1  

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