Počet záznamů: 1
Novel antimicrobial peptides
- 1.0394191 - ÚOCHB 2014 RIV eng P - Patentový dokument
Monincová, Lenka - Čeřovský, Václav - Slaninová, Jiřina - Hovorka, Oldřich - Cvačka, Josef - Voburka, Zdeněk - Fučík, Vladimír - Borovičková, Lenka
Novel antimicrobial peptides.
2013. Vlastník: Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Datum udělení patentu: 06.03.2013. Číslo patentu: EP2396020
Grant CEP: GA ČR GA203/08/0536
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: antimicrobial peptides * bee venom * hemolytic activity * NMR spectroscopy * CD spectroscopy
Kód oboru RIV: CE - Biochemie
http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20130306&DB=EPODOC&locale=en_EP&CC=EP&NR=2396020B1&KC=B1&ND=4
The invention involves two novel peptides of the formulas H-Gly -Met-Trp -Ser-Lys-Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 (I) and H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 (II) isolated from venom reservoirs of primitively eusocial bees Halictus sexcintus and their synthetic analogs possessing biological effects, prepared by the substitution of an amino acid in position 4, 11 or 12 of formula (I) or in position 4 of formula (II) by an amino acid lysine. Described is also their usage for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.
Trvalý link: http://hdl.handle.net/11104/0222491
Počet záznamů: 1