Monotopic modifications derived from in vitro glycation of albumin with ribose

0394058 - FGÚ 2014 RIV DE eng J - Článek v odborném periodiku
Pataridis, Statis - Šťastná, Zdeňka - Sedláková, Pavla - Mikšík, Ivan
Monotopic modifications derived from in vitro glycation of albumin with ribose.
Electrophoresis. Roč. 34, č. 12 (2013), s. 1757-1763. ISSN 0173-0835. E-ISSN 1522-2683
Grant CEP: GA ČR(CZ) GAP206/12/0453; GA ČR(CZ) GA203/08/1428
Institucionální podpora: RVO:67985823
Klíčová slova: advanced glycation end product (AGE) * albumin * CE-MS * glycation * LC-MS/MS
Kód oboru RIV: CB - Analytická chemie, separace
Impakt faktor: 3.161, rok: 2013

The glycation of albumins (HSA and BSA) was studied by nano-LC coupled to a QTOF mass spectrometer. Non-enzymatic in vitro reaction products between albumin and ribose were identified. Besides well-known carboxymethyl lysine, new modifications were determined –creating mass shifts of 78 and 218. The origin of the first modification is discussed and its possible structure is presented. Another mass shift of 132 belonged to a Schiff base
Trvalý link: http://hdl.handle.net/11104/0222379