Completion of cell division is associated with maximum telomerase activity in naturally synchronized cultures of the green alga Desmodesmus quadricauda

0392622 - BFÚ 2014 RIV NL eng J - Článek v odborném periodiku
Ševčíková, Tereza - Bišová, Kateřina - Fojtová, Miloslava - Lukešová, Alena - Hrčková, Kristýna - Sýkorová, Eva
Completion of cell division is associated with maximum telomerase activity in naturally synchronized cultures of the green alga Desmodesmus quadricauda.
FEBS Letters. Roč. 587, č. 6 (2013), s. 743-748. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA ČR(CZ) GA521/09/1912; GA MŠMT(CZ) ED1.1.00/02.0068
Výzkumný záměr: CEZ:AV0Z50040702
Institucionální podpora: RVO:68081707 ; RVO:60077344 ; RVO:61388971
Klíčová slova: SCENEDESMUS-QUADRICAUDA * CYCLE * CHLAMYDOMONAS
Kód oboru RIV: BO - Biofyzika; EE - Mikrobiologie, virologie (MBU-M)
Impakt faktor: 3.341, rok: 2013

Telomerase maintains the ends of eukaryotic chromosomes, and its activity is an important parameter correlating with the proliferative capacity of cells. We have investigated cell cycle-specific changes in telomerase activity using cultures of Desmodesmus quadricauda, a model alga naturally synchronized by light/dark entrainment. A quantitative telomerase assay revealed high activity in algal cultures, with slight changes during the light period. Significantly increased telomerase activity was observed at the end of the dark phase, when cell division was complete. In contrast to other models, a natural separation between nuclear and cellular division typical for the cell cycle in D. quadricauda made this observation possible. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Trvalý link: http://hdl.handle.net/11104/0221426