Počet záznamů: 1
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt
- 1.0392596 - FGÚ 2014 RIV CH eng J - Článek v odborném periodiku
Wasková-Arnoštová, P. - Elsnicová, B. - Kašparová, D. - Šebesta, O. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt.
Cellular Physiology and Biochemistry. Roč. 31, č. 1 (2013), s. 66-79. ISSN 1015-8987
Grant CEP: GA AV ČR(CZ) IAAX01110901
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: hexokinase isoforms * akt kinase * left ventricle * right ventricle * mitochondria co-localization
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 3.550, rok: 2013
The purpose of this study was to investigate expression and subcellular localization of both HK isoforms in left (LV) and right (RV) heart ventricles of adult male Wistar rats. Our results showed a significantly higher expression of both HK1 and HK2 at mRNA and protein levels in the RV compared to the LV. These results suggest that the RV has a higher activity of aerobic glycolytic metabolism and may be able to respond faster and more powerfully to stressful stimuli than the LV
Trvalý link: http://hdl.handle.net/11104/0221432
Počet záznamů: 1