Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury

0392285 - FGÚ 2014 RIV GB eng J - Článek v odborném periodiku
Borchert, Gudrun H. - Hlaváčková, Markéta - Kolář, František
Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury.
Experimental Biology and Medicine. Roč. 238, č. 2 (2013), s. 233-241. ISSN 1535-3702. E-ISSN 1535-3699
Grant CEP: GA AV ČR(CZ) IAA500110804; GA ČR(CZ) GAP303/12/1162
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: potassium channels * cardiomyocytes * mitochondria * ischemia/reperfusion * cytoprotection * reactive oxygen species
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 2.226, rok: 2013

The results indicate that pharmacological activation of mitochondrial large-conductance calcium-activated potassium channels effectively protects isolated cardiomyocytes against injury associated with simulated reperfusion. The mechanism of this form of protection requires signaling via reactive oxygen species, but not the activation of the pro-survival phosphatidylinositol-3-kinase pathway
Trvalý link: http://hdl.handle.net/11104/0221192