How insulin engages its primary binding site on the insulin receptor

0391760 - ÚOCHB 2014 RIV GB eng J - Článek v odborném periodiku
Menting, J. G. - Whittaker, J. - Margetts, M. B. - Whittaker, L. J. - Kong, G. K. W. - Smith, B. J. - Watson, C. J. - Žáková, Lenka - Kletvíková, Emília - Jiráček, Jiří - Chan, S. J. - Steiner, D. F. - Dodson, G. G. - Brzozowski, A. M. - Weiss, M. A. - Ward, C. W. - Lawrence, M. C.
How insulin engages its primary binding site on the insulin receptor.
Nature. Roč. 493, č. 7431 (2013), s. 241-245. ISSN 0028-0836. E-ISSN 1476-4687
Grant CEP: GA ČR GPP207/11/P430
Institucionální podpora: RVO:61388963
Klíčová slova: insulin * receptor * complex * crystal structure
Kód oboru RIV: CE - Biochemie
Impakt faktor: 42.351, rok: 2013

Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Here we present the first view, to our knowledge, of the interaction of insulin with its primary binding site on the insulin receptor, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs.
Trvalý link: http://hdl.handle.net/11104/0220731