Pediatric Epilepsy Surgery

0390006 - FGÚ 2013 RIV AT eng M - Část monografie knihy
Kubová, Hana - Lukasiuk, K. - Pitkänen, A.
New Insight on the Mechanisms of Epileptogenesis in the Developing Brain.
Pediatric Epilepsy Surgery. Wien: Springer, 2012 - (Nelat, A.; Di Rocco, C.), s. 3-44. Advances and Technical Standards in Neurosurgery, Vol.39. ISBN 978-3-7091-1359-2
Grant CEP: GA ČR(CZ) GAP302/10/0971; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ME08045
Institucionální podpora: RVO:67985823
Klíčová slova: epileptogenesis * developing brain
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

The incidence of epilepsy is at its highest in childhood and seizures can persist for a lifetime. As brain tissue from pediatric patients with epilepsy is rarely available, the analysis of molecular and cellular changes during epileptogenesis, which could serve as targets for treatment approaches, has to rely largely on the analysis of tissue from animal models. However, these data have to be analyzed in the context of the developmental stage when the insult occurs. Here we review the current status of the available animal models, the molecular analysis done in these models, as well as treatment attempts to prevent epileptogenesis in the immature brain
Trvalý link: http://hdl.handle.net/11104/0218940