Recent Advances on Model Hosts

0389980 - BC 2013 RIV DE eng M - Část monografie knihy
Kopáček, Petr - Hajdušek, Ondřej - Burešová, Veronika
Tick as a Model for the Study of a Primitive Complement System.
Recent Advances on Model Hosts. Berlin: Springer-Verlag, 2013 - (Mylonakis, E.; Ausubel, F.; Gilmore, M.; Casadevall, A.), s. 83-93. ISBN 978-1-4419-5638-5
Grant CEP: GA MŠMT(CZ) LC06009; GA ČR GAP506/10/2136
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: vector anopheles-gambiae * Ornithodoros moubata * Ixodes ricinus * innate immunity * dorim M * Chryseobacterium indologenes * molecular characterization * component C3 * phagocytosis P * hemocytes
Kód oboru RIV: EB - Genetika a molekulární biologie

Ticks are blood feeding parasites transmitting a wide variety of pathogens to their vertebrate hosts. The transmitted pathogens apparently evolved efficient mechanisms enabling them to evade or withstand the cellular or humoral immune responses within the tick vector. Despite its importance, our knowledge of tick innate immunity still lags far beyond other well established invertebrate models, such as drosophila, horseshoe crab or mosquitoes. However, the recent release of the American deer tick, Ixodes scapularis, genome and feasibility of functional analysis based on RNA interference (RNAi) facilitate the development of this organism as a full-value model for deeper studies of vector-pathogen interactions.
Trvalý link: http://hdl.handle.net/11104/0218870