Počet záznamů: 1
Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth
- 1.0388553 - FGÚ 2013 RIV CZ eng J - Článek v odborném periodiku
Kagan, Dmytro - Dlouhá, Kateřina - Roubalová, Lenka - Svoboda, Petr
Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth.
Physiological Research. Roč. 61, č. 6 (2012), s. 629-635. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP207/12/0919
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: postnatal development * GABAB-receptors * G-protein coupling/activation * baclofen * SKF97541
Kód oboru RIV: CE - Biochemie
Impakt faktor: 1.531, rok: 2012
Our data indicate the significant intrinsic efficacy of GABAB-receptors in rat brain cortex already at birth (PD1, PD2). The potency of G-protein response to baclofen (characterized by EC50 values) was also high at birth but unchanged by further postnatal development. The highest plasma membrane density of GABAB-R was measured in 1-day old animals
Trvalý link: http://hdl.handle.net/11104/0217456
Počet záznamů: 1