Two new halocuprates complexes [Cu.sup.II./sup.(1,4,8,11-tetraazacyclotetradecane)][Cu.sup.I ./sup.Cl.sub.3./sub.] and [H.sub.4./sub.(1,4,8,11-tetrazacyclotetradecane)][Cu.sup.I ./sup..sub.2./sub.Cl.sub.6./sub.]: synthesis, characterizations and biological studies

0388275 - FZÚ 2013 RIV US eng J - Článek v odborném periodiku
Lachkar, M. - Halime, I. - Bezgour, A. - El Bali, B. - Dušek, Michal - Fejfarová, Karla - Siddiq, S. - Marasini, B.P. - Noreen, S. - Khan, A. - Rasheed, S. - Choudhary, M.I.
Two new halocuprates complexes [Cu^II(1,4,8,11-tetraazacyclotetradecane)][Cu^I Cl₃] and [H₄(1,4,8,11-tetrazacyclotetradecane)][Cu^I ₂Cl₆]: synthesis, characterizations and biological studies.
Medicinal Chemistry Research. Roč. 21, č. 12 (2012), s. 4290-4300. ISSN 1054-2523. E-ISSN 1554-8120
Grant ostatní: AV ČR(CZ) AP0701
Program: Akademická prémie - Praemium Academiae
Výzkumný záměr: CEZ:AV0Z10100521
Klíčová slova: mixed valence * copper(I/II) complexes * halocuprates * tetraazacyclotetradecane * x-ray structures * beta-glucuronidase * enzyme inhibition
Kód oboru RIV: BM - Fyzika pevných látek a magnetismus
Impakt faktor: 1.612, rok: 2012

Synthesis, crystal structures and biological activities for the new chlorobridged mixed valence CuI/CuII coordination polymer [CuIIcyclam][CuICl3] 1 and [H4cyclam][Cu2 I Cl6] 2 are reported. Compound 1 crystallizes in the orthorhombic system, space group Pccn. Its crystal structure consists of one-dimensional polymer CuIIcyclam–Cl–CuI–Cl–CuIIcyclam. Compound 2 is monoclinic (P21/n)with the tetraprotonated cyclam H4cyclam(4+) in (3,4,3,4)-B conformation. Compound 1 was tested to understand its influence on enzyme activity, immunomodulation as well as its toxicity and antiglycation potential. Its effect was significant as immunomodulatory and inhibitory activity against b-glucuronidase enzyme.
Trvalý link: http://hdl.handle.net/11104/0217129