Počet záznamů: 1  

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

  1. 1.
    0387858 - ÚMG 2013 RIV DE eng J - Článek v odborném periodiku
    Valach, J. - Fík, Z. - Strnad, Hynek - Chovanec, M. - Plzák, J. - Čada, Z. - Szabo, Pavol - Šáchová, Jana - Hroudová, Miluše - Urbanová, Markéta - Steffl, M. - Pačes, Jan - Mazánek, J. - Vlček, Čestmír - Betka, J. - Kaltner, H. - André, S. - Gabius, H. J. - Kodet, R. - Smetana, K. - Gál, P. - Kolář, Michal
    Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors.
    International Journal of Cancer. Roč. 131, č. 11 (2012), s. 2499-2508. ISSN 0020-7136. E-ISSN 1097-0215
    Grant CEP: GA MŠMT 2B06106
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: carcinoma * stroma * actin * lectin
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 6.198, rok: 2012

    Tumor stroma is an active part influencing the biological properties of malignancies via molecular cross-talk. Cancer-associated fibroblasts play a significant role in this interaction. These cells frequently express smooth muscle actin and can be classified as myofibroblasts. The adhesion/growth-regulatory lectin galectin-1 is an effector for their generation. In our study, we set the presence of smooth muscle actin-positive cancer-associated fibroblasts in relation to this endogenous lectin and an in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence was highly significantly correlated to presence of smooth muscle actin-positive cancer-associated fibroblasts in the tumor (p = 4 x 10-8). To pinpoint further correlations on the molecular level, we applied microarray analyses to the transcription profiles of the corresponding tumors. Significant correlations of several transcripts were detected with the protein level of galectin-1 in the cancer-associated fibroblasts. These activated genes (MAP3K2, TRIM23, PTPLAD1, FUSIP1, SLC25A40 and SPIN1) are related to known squamous-cell-carcinoma poor-prognosis factors, NF-kappa B upregulation and splicing downregulation. These results provide new insights into the significance of presence of myofibroblasts in squamous cell carcinoma.
    Trvalý link: http://hdl.handle.net/11104/0218443

     
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