Changes in Temperature Have Opposing Effects on Current Amplitude in alpha 7 and alpha 4 beta 2 Nicotinic Acetylcholine Receptors

0387214 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Jindřichová, Marie - Lansdell, S. J. - Millar, N. S.
Changes in Temperature Have Opposing Effects on Current Amplitude in alpha 7 and alpha 4 beta 2 Nicotinic Acetylcholine Receptors.
PLoS ONE. Roč. 7, č. 2 (2012), e32073. ISSN 1932-6203. E-ISSN 1932-6203
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: effect of temperature * nicotinic acetylcholine receptor * voltage-clamp recording
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.730, rok: 2012

We have examined the effect of temperature on the electrophysiological properties of three neuronal nicotinic acetylcholine receptor (nAChR) subtypes: the rapidly desensitizing homomeric alfa7 nAChR, the more slowly desensitizing heteromeric alfa4beta2 nAChR and on alfa7 nAChRs containing a transmembrane mutation (L247T) that results in dramatically reduced desensitization. Despite the differing effects of temperature on the amplitude of agonist-evoked responses in different nAChRs, changes in temperature had a consistent effect on the rate of receptor desensitization on all subtypes examined
Trvalý link: http://hdl.handle.net/11104/0218367