Chiral analysis of beta-alanyl-D,L-tyrosine and its derivatives by capillary electrophoresis with 2-hydroxypropyl-beta-cyclodextrin stereoselector

0387195 - ÚOCHB 2013 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Sázelová, Petra - Šolínová, Veronika - Schimperková, Tereza - Mášová, Alice - Jiráček, Jiří - Kašička, Václav
Chiral analysis of beta-alanyl-D,L-tyrosine and its derivatives by capillary electrophoresis with 2-hydroxypropyl-beta-cyclodextrin stereoselector.
Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 50S. Olomouc: Faculty of Science, Palacký University Olomouc, 2012 - (Maier, V.; Ševčík, J.), s. 148-149. ISBN 978-80-244-3115-4. ISSN 0232-0061.
[International Symposium Advances in Chromatography and Electrophoresis and Chiranal. Olomouc (CZ), 11.06.2012-14.06.2012]
Grant CEP: GA ČR(CZ) GA203/08/1428; GA ČR(CZ) GAP206/12/0453
Institucionální podpora: RVO:61388963
Klíčová slova: capillary zone electrophoresis * antimicrobial peptides * chiral analysis
Kód oboru RIV: CB - Analytická chemie, separace

A new capillary electrophoretic method was developed for separation of enantiomers of antimicrobial dipeptide betha-Ala-D,L-Tyr and its derivatives using 50 mM Tris-phosphate, pH 2.50, as background electrolyte and 2-hydroxypropyl-betha-cyclodextrin at concentrations 20 – 60 mg/mL as chiral selector. In addition, association constants of complexes of the enatiomers of dipeptide betha-Ala-D,L-Tyr and its derivatives with 2-hydroxypropyl-betha-cyclodextrin chiral selector were determined.
Trvalý link: http://hdl.handle.net/11104/0216660