A simple device for quantitation of Caspase 3 in individual apoptotic embryonic cells

0386270 - ÚIACH 2013 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Hegrová, Jitka - Klepárník, Karel - Přikryl, Jan - Lišková, Marcela - Matalová, Eva - Foret, František
A simple device for quantitation of Caspase 3 in individual apoptotic embryonic cells.
CECE 2012. 9th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i, 2012 - (Foret, F.; Křenková, J.; Guttman, A.; Klepárník, K.; Boček, P.), s. 354-356. ISBN 978-80-904959-1-3.
[CECE 2012. International Interdisciplinary Meeting on Bioanalysis /9./. Brno (CZ), 01.11.2012-02.11.2012]
Grant CEP: GA ČR(CZ) GAP301/11/2055; GA ČR GAP206/11/2377; GA ČR(CZ) GPP206/11/P002
Institucionální podpora: RVO:68081715 ; RVO:67985904
Klíčová slova: single cell * chemiluminiscence * Caspase 3
Kód oboru RIV: CB - Analytická chemie, separace

A newly developed system for the determination of Caspase 3 activity in individual apoptotic embryonic cells is described. Caspase 3, a cysteine-aspartic acid protease activated in the apoptotic pathway, plays an essential role in the programmed cell death. Moreover, failure of apoptosis is one of the main contributions to tumor development.
Trvalý link: http://hdl.handle.net/11104/0215496